Metal-free O-H/C-H difunctionalization of phenols by o-hydroxyarylsulfonium salts in water.
نویسندگان
چکیده
An environmentally benign method for C-H/O-H difunctionalization of phenols with sulfoxides under mild conditions has been developed. The reaction process is mediated by an electrophilic aromatic substitution and subsequent selective aryl or alkyl migration, involving C-S and C-O bond formations with broad substrate scope.
منابع مشابه
Metal-free O–H/C–H difunctionalization of phenols by o-hydroxyarylsulfonium salts in water† †Electronic supplementary information (ESI) available. CCDC 1502491, 1502489 and 1502490. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04504a Click here for additional data file. Click here for additional data file.
hemistry 2017 been widely used to construct important families of target molecules, aryl ethers, suldes and sulfoxides. Traditionally, these reactions are carried out in organic solvents (e.g., THF, CH3CN, DMSO, and DMF), which may cause potential health, safety, and waste disposal issues. Therefore, transition-metalfree C–O and C–S coupling reactions under greener conditions are desirable, es...
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ورودعنوان ژورنال:
- Chemical science
دوره 8 2 شماره
صفحات -
تاریخ انتشار 2017